Linear 1 3-diarylpropanoids
Medchemexpress LLC Naringenin | 480-41-1 | MFCD00006844 | 272.25 | 100 MG
Naringenin, a predominant flavanone found in Citrus reticulata Blanco, exhibits strong anti-inflammatory and antioxidant activities. It also demonstrates anti-dengue virus (DENV) activity. Research indicates Naringenin can inhibit proliferation of HepG2 cells by inducing G0/G1 and G2/M phase accumulation and apoptosis. It also reduces viability of A431 cells and has shown potential to reduce plasma and liver triglycerides, cholesterol, and adiposity.
- Displays strong anti-inflammatory and antioxidant activities.
- Exhibits anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Induces G0/G1 and G2/M phase accumulation.
- Reduces A431 cell viability.
- Reduces plasma and liver triglycerides and cholesterol.
- Increases hepatic PPARα protein expression.
- Inhibits TNF-α-induced VSMC proliferation.
Medchemexpress LLC Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) | 4197-97-1 | 5 MG
Pinocembrin chalcone (2',4',6'-Trihydroxychalcone) is an antibacterial compound isolated from Helichrysum Trilineatum. It facilitates AMP-activated protein kinase (AMPK) activation, which improves glucose tolerance, increases muscle fatty acid oxidation (FAO), and reduces fat accumulation in the liver and skeletal muscles of high-fat diet-induced (HFD) diabetic mice. These properties make Pinocembrin chalcone a promising compound for research related to gastric ulcers and diabetes.
- Antibacterial activity: Inhibits the growth of S. aureus in vitro.
- Metabolic regulation: Significantly increases the fatty acid oxidation rate and enhances the phosphorylation of AMPKα in C2C12 myotubes.
- Anti-diabetic effects: Improves glucose tolerance and reduces fat accumulation in the liver and muscles in HFD-induced diabetic mice.
Medchemexpress LLC Naringenin | 480-41-1 | 99.3% | 272.25 | 1 G
Naringenin is the predominant flavanone found in *Citrus reticulata Blanco*. It exhibits strong anti-inflammatory and antioxidant activities, and also possesses anti-dengue virus (DENV) activity.
- Exhibits strong anti-inflammatory activity.
- Exhibits strong antioxidant activity.
- Possesses anti-dengue virus (DENV) activity.
- Inhibits HepG2 cell proliferation.
- Reduces plasma and liver triglycerides and cholesterol.
- Enhances hepatic fatty acid oxidation.
Medchemexpress LLC AKT-IN-23 | 1226801-23-5 | 517.52 | 25 MG
AKT-IN-23 is an AKT inhibitor primarily used in cancer research. This compound is known for its specific targeting capabilities.
- Acts as an AKT inhibitor
- Suitable for cancer research applications
- Targets Akt
- Involves the PI3K/Akt/mTOR pathway
![Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387556-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 3-Pyridinecarboxamide, 6-[4-(1-aminocyclobutyl)phenyl]-5-pheny | 1357158-81-6 | 98.4% | 343.42 | 1 ML
AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM. It potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473. In vivo, it causes significant tumor growth inhibition in breast adenocarcinoma xenograft models.
- Allosteric AKT inhibitor.
- Potently inhibits phosphorylation of AKT in cells at both Thr308 and Ser473, with IC50s of 0.422 and 0.322 μM respectively.
- Inhibits the phosphorylation of ribosomal protein S6, a downstream effector of the PI3K-AKT pathway.
- Potently inhibits the phosphorylation of PRAS40.
- In vivo, potently inhibits the phosphorylation of its downstream substrate GSK3β as well as the phosphorylation of AKT (Ser473).
- Causes significant tumor growth inhibition in BT474c breast adenocarcinoma xenograft models when dosed at 200 mg/kg daily.
TARGETMOL CHEMICALS INC 4 4 -Dimethoxychalcone 50MG
Also available in 1 mL, 25 mg, 100 mg and bulk. Please contact Fisher for quotes.4,4'-Dimethoxychalcone (4,4-Dimethoxychalcone) is a natural product. Purity 99.35%
Apexbio Technology LLC trans-Chalcone 614-47-1 5g
trans-Chalcone (CAS 614-47-1) is a small-molecule inhibitor targeting fatty acid synthase (FAS) and -amylase It is designed to inhibit enzymatic activity thereby regulating lipid metabolism and carbohydrate processing trans-Chalcone exerts its biological activity primarily through inhibition of FAS and -amylase In cell-based studies trans-Chalcone demonstrates induction of cell cycle arrest and apoptosis in MCF-7 breast cancer cells Based on these pharmacological properties trans-Chalcone holds research potential in oncology enzymatic inhibition studies and cell-cycle regulation analysis
Apexbio Technology LLC trans-13-docosenoic acid 506-33-2 10mg
trans-13-docosenoic acid is a long-chain monounsaturated fatty acid It is used experimentally to study lipid metabolism pathways cellular membrane processes and lipid signaling mechanisms in biological systems trans-13-docosenoic acid also serves as an analytical standard in lipidomics studies to identify and quantify fatty acid profiles in biological samples Based on these properties trans-13-docosenoic acid holds research potential in the development of lipid-based delivery systems surfactants and topical pharmaceutical and cosmetic preparations
Medchemexpress LLC Rac-brassinazole | 224047-41-0 | >98.0% | 10MG
Rac-brassinazole | 224047-41-0 | >98.0% | 10MG